The death of a loved one.

A divorce, separation, or breakup of a relationship.

Losing custody of children, or feeling that a child custody decision is not fair.

A serious loss, such as a loss of a job, house, or money.

A serious illness.

A terminal illness.

A serious accident.

Chronic physical pain.

Intense emotional pain.

Loss of hope.

Being victimized (domestic violence, rape, assault, etc).

A loved one being victimized (child murder, child molestation, kidnapping, murder, rape, assault, etc.).

Physical abuse.

Verbal abuse.

Sexual abuse.

Unresolved abuse (of any kind) from the past.

Feeling "trapped" in a situation perceived as negative.

Feeling that things will never "get better."

Feeling helpless.

Serious legal problems, such as criminal prosecution or incarceration.

Feeling "taken advantage of."

Inability to deal with a perceived "humiliating" situation.

Inability to deal with a perceived "failure."

Alcohol abuse.

Drug abuse.

A feeling of not being accepted by family, friends, or society.

A horrible disappointment.

Feeling like one has not lived up to his or her high expectations or those of another.

Bullying. (Adults, as well as children, can be bullied.)

Low self-esteem.